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Updated: Aug 21, 2026

Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease
Published on: April 17, 2017
[Selective volitional respiration control loss (inverse Ondiene's curse syndrome) in amyotrophic lateral sclerosis]
Masaaki Konagaya1, Fumihiko Yasuma, Motoko Sakai
1Department of Neurology, Suzuka National Hospital, 3-2-1 Kasado, Suzuka, Mie 513-8501, Japan.
Abstract:
We investigated neuro-respiratory function of a 60-year-old woman with a 7-year-history of amyotrophic lateral sclerosis. She was trachomized 4 years ago, however, spontaneous respiration had been observed. Plethysmography disclosed autonomous and abolished volitional control on breathing. Cough reflex and emotional laughing influenced on respiration pattern. Positive reaction of respiration to hypercapnia was observed. Then, it seemed to be preserved respiratory neurons in the medulla oblongata and bulbospinal tract, and remarkable impairement of the corticospinal tract.
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