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Related Experiment Videos

Mouse tooth development time sequence determination for the ICR/Jcl strain.

Marcia Gaete1, Nelson Lobos, María Angélica Torres-Quintana

  • 1Department of Pathology, Dental School, University of Chile, Santiago, Chile.

Journal of Oral Science
|October 29, 2004
PubMed
Summary

This study details the dental development timeline for the ICR/Jcl mouse strain, establishing a normal pattern for the first mandibular molar. This research provides a crucial reference for understanding mouse embryonic and dental development, particularly in transgenic models.

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Area of Science:

  • Developmental Biology
  • Comparative Anatomy
  • Genetics

Background:

  • Understanding the precise timing of embryonic development is crucial for research involving animal models.
  • The ICR/Jcl mouse strain is widely used in biomedical research, but its specific dental development pattern requires detailed characterization.
  • Establishing a normative developmental timeline aids in identifying abnormalities and assessing the impact of genetic modifications.

Purpose of the Study:

  • To meticulously document the chronological stages of first mandibular molar development in the ICR/Jcl mouse strain.
  • To create a detailed reference for normal embryonic and postnatal dental development in this specific mouse strain.
  • To provide a baseline for future studies utilizing ICR/Jcl mice, especially in genetic research.

Main Methods:

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  • Observation and daily recording of developmental stages of the first mandibular molar.
  • Analysis of embryonic and postnatal specimens from gestation day 12.5 through several days after birth.
  • Accurate chronological mapping of key developmental events, including proliferation, bud, cap, bell stages, and mineralization.

Main Results:

  • Dental sheet proliferation initiated at embryonic day 12.5 (E-12.5).
  • Bud, cap, and early bell stages occurred between E-13.5 and E-17.5.
  • Dentin formation was observed by postnatal days 1-2 (D-1, D-2), with enamel present after D-3.
  • ICR/Jcl mouse dental development is notably faster than in other common strains.

Conclusions:

  • The established developmental pattern provides a precise timeline for ICR/Jcl mouse mandibular molar formation.
  • This detailed chronology serves as a valuable resource for researchers working with ICR/Jcl mice.
  • The accelerated development observed in this strain has implications for experimental design in transgenic mouse studies.