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Updated: Aug 19, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Squamous cell carcinoma of the skin
1Division of Plastic and Reconstructive Surgery at Scripps Clinic and at the University of California San Diego, La Jolla, Calif, USA. rrudolph@scrippsclinic.com
Learning Objectives:
After studying this article, the participant should be able to: 1. Identify the subtypes of squamous cell carcinoma of the skin. 2. Identify factors that affect recurrence and/or metastasis. 3. Develop a surgical management plan for treating high-risk squamous cell carcinoma of the skin. In treating squamous cell carcinoma of the skin, a key concept in proper management is understanding why certain tumors are more prone to both recurrence and metastasis. When developing a surgical management plan, an understanding of "high risk" is essential. This article concentrates on identifying those tumor subtypes and factors that may serve as predictors of high-risk status as well as on providing management suggestions.
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