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[Nicardipine-induced gingival hyperplasia: case report].
B Maguin1, J Yachouh, P Goudot
1Service de Chirurgie Maxillo-Faciale et Stomatologie, Hôpital Lapeyronie, 371, av. du Doyen Gaston Giraud, 34295 Montpellier, France.
Revue De Stomatologie Et De Chirurgie Maxillo-Faciale
|October 29, 2004
Summary
Drug-induced gingival hyperplasia can be caused by various medications, including calcium antagonists like nicardipine. Surgical removal is often the last resort when other treatments fail.
Area of Science:
- Pharmacology
- Oral Medicine
- Drug-induced Diseases
Background:
- Gingival hyperplasia is a known side effect of several drug classes.
- Therapeutic agents commonly implicated include anticonvulsants, immunosuppressants like cyclosporine, and certain calcium channel blockers.
Observation:
- This report details an uncommon case of drug-induced gingival hyperplasia attributed to nicardipine, a specific calcium antagonist.
- The patient presented with excessive gingival tissue growth linked to nicardipine use.
Findings:
- Nicardipine, a dihydropyridine calcium antagonist, can induce gingival overgrowth.
- Other calcium antagonists and drug classes like anticonvulsants and cyclosporine are also associated with this adverse effect.
Implications:
- When drug cessation or substitution is not feasible, and prophylactic measures are ineffective, surgical gingivectomy is the primary treatment for drug-induced gingival hyperplasia.
- This highlights the importance of monitoring patients for gingival changes during treatment with implicated medications.