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Updated: Mar 23, 2026

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Published on: September 28, 2022

Epstein-Barr virus: 40 years on.

Lawrence S Young¹, Alan B Rickinson

¹Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, B15 2TT, UK. l.s.young@bham.ac.uk

Nature Reviews. Cancer

|October 29, 2004

Summary

Epstein-Barr virus (EBV), discovered 40 years ago, is linked to Burkitt's lymphoma. This widespread gamma-herpesvirus infects most humans lifelong, associating with various tumors.

Area of Science:

Virology
Oncology
Immunology

Background:

Epstein-Barr virus (EBV) was first identified 40 years ago in cells from Burkitt's lymphoma.
The geographical distribution of Burkitt's lymphoma, common in sub-Saharan Africa, suggested a viral cause, correlating with malaria prevalence.

Purpose of the Study:

To investigate the discovery and widespread nature of Epstein-Barr virus (EBV).
To explore the association between EBV and various tumors, starting with Burkitt's lymphoma.

Main Methods:

Electron microscopy of cells cultured from Burkitt's lymphoma.
Epidemiological studies on EBV distribution and its correlation with malaria.
Observational studies on EBV infection and tumor associations.

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Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

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Main Results:

EBV was discovered from Burkitt's lymphoma cell cultures.
EBV is a widespread gamma-herpesvirus found in most human populations.
EBV establishes lifelong, asymptomatic infections in B-lymphocytes.
The association between EBV and endemic Burkitt's lymphoma is consistent.
EBV is linked to a wide range of other tumors.

Conclusions:

Epstein-Barr virus (EBV) is a ubiquitous human pathogen with a significant role in oncogenesis.
The discovery of EBV's link to Burkitt's lymphoma opened the door to understanding its broader carcinogenic potential.