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Updated: Mar 18, 2026

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics
Published on: December 1, 2023
High interstitial fluid pressure - an obstacle in cancer therapy
Carl-Henrik Heldin1, Kristofer Rubin, Kristian Pietras
1Ludwig Institute for Cancer Research, Box 595, SE-751 24 Uppsala, Sweden. C-H.Heldin@licr.uu.se
Abstract:
Many solid tumours show an increased interstitial fluid pressure (IFP), which forms a barrier to transcapillary transport. This barrier is an obstacle in tumour treatment, as it results in inefficient uptake of therapeutic agents. There are a number of factors that contribute to increased IFP in the tumour, such as vessel abnormalities, fibrosis and contraction of the interstitial matrix. Lowering the tumour IFP with specific signal-transduction antagonists might be a useful approach to improving anticancer drug efficacy.
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