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Assessing Bacterial Invasion of Cardiac Cells in Culture and Heart Colonization in Infected Mice Using Listeria monocytogenes
09:18

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Outcome of Listeria monocytogenes prosthetic valve endocarditis: as bad as it looks?

Jose M De Miguel-Yanes1, Víctor J González-Ramallo, Luis Pastor

  • 1Emergency Department, Hospital General Universitario "Gregorio Marañón", Madrid, Spain. jmdmiguel@i4con.com

Scandinavian Journal of Infectious Diseases
|October 30, 2004
PubMed

Insights

Listeria monocytogenes prosthetic valve endocarditis has a lower mortality rate than previously thought. Peripheral embolism and mechanical prosthesis onset are linked to mortality, while combination antibiotic therapy is recommended.

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Microbiology

Background:

  • Listeria monocytogenes can cause prosthetic valve endocarditis (PVE).
  • Previous reviews established baseline understanding of PVE due to this pathogen.
  • An updated review is necessary to assess current outcomes and risk factors.

Purpose of the Study:

  • To conduct an up-to-date review of Listeria monocytogenes PVE cases.
  • To determine the current mortality rate associated with this condition.
  • To identify clinical and therapeutic variables associated with mortality.

Main Methods:

  • PubMed database search for Listeria monocytogenes PVE cases.
  • Calculation of overall mortality rate.
  • Fisher's exact test to identify significant variables associated with mortality.

Main Results:

  • A total of 23 cases were reviewed.
  • The in-hospital mortality rate was 17% (4 out of 23 patients).
  • Peripheral embolism, mechanical prosthesis onset, and monotherapy with antibiotics were significantly associated with mortality.

Conclusions:

  • The mortality rate for Listeria monocytogenes PVE may be lower than previously reported.
  • Traditional poor prognostic factors for endocarditis may not apply to this specific condition.
  • Combination antibiotic therapy (e.g., ampicillin or vancomycin plus an aminoglycoside) is recommended.

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