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Factors affecting clinical and therapeutic outcomes of patients with juvenile rheumatoid arthritis

C-T Hsu1, Y-T Lin, Y-H Yang

  • 1Department of Pediatrics, National Taiwan University Hospital, Taipei, Republic of China.

Scandinavian Journal of Rheumatology
|October 30, 2004
PubMed

Insights

This study examined juvenile rheumatoid arthritis (JRA) in Taiwanese children, finding oligoarticular onset most common. Factors like HLA-B27 and high CRP levels impacted remission success.

Area of Science:

  • Pediatrics
  • Rheumatology
  • Immunology

Background:

  • Juvenile rheumatoid arthritis (JRA) presents unique challenges in pediatric populations.
  • Understanding JRA's clinical spectrum and treatment responses is crucial for effective management.

Purpose of the Study:

  • To investigate the clinical features, medications used, and therapeutic outcomes of JRA in Taiwanese children.
  • To identify factors associated with treatment response and remission in this cohort.

Main Methods:

  • Retrospective chart review of children newly diagnosed with JRA.
  • Data collected from National Taiwan University Hospital between 1996 and 2001.
  • Analysis of demographic data, disease characteristics, treatment regimens, and remission status.

Main Results:

  • Oligoarticular onset was the most frequent JRA subtype.
  • A bimodal age distribution at onset was observed (peaks at 4 and 10 years).
  • Sixty-nine percent achieved clinical remission; factors predicting failure included HLA-B27, high CRP, and thrombocytosis at diagnosis.

Conclusions:

  • Taiwanese children with JRA exhibit distinct phenotypic features.
  • Human leukocyte antigen B27 (HLA-B27), elevated C-reactive protein (CRP), and thrombocytosis are associated with treatment resistance.
Abstract

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