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Related Experiment Videos

Nanoparticle-coated microparticles: preparation and characterization.

R C R Beck1, A R Pohlmann, S S Guterres

  • 1Programa de Pós-Graduação em Ciências Farmacêuticas. Faculdade de Farmácia, Porto Alegre, RS, Brazil.

Journal of Microencapsulation
|October 30, 2004
PubMed
Summary
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New nanoparticle-coated microparticles were developed using spray-drying for controlled drug delivery. This method enhances gastroresistance for diclofenac formulations, showing technological feasibility for pharmaceutical applications.

Area of Science:

  • Pharmaceutical Technology
  • Materials Science
  • Drug Delivery Systems

Background:

  • Previous research focused on spray-drying drug-loaded polymeric nanoparticles with silicon dioxide.
  • This study innovates by associating the drug with silicon dioxide and using unloaded polymeric nanocapsules/nanospheres for organic coating.

Purpose of the Study:

  • To design and prepare novel nanoparticle-coated, drug-loaded inorganic microparticles via spray-drying.
  • To evaluate the potential of polymeric colloidal suspensions as microparticle nanocoatings.
  • To assess the gastroresistance and in vitro drug release of the developed formulations.

Main Methods:

  • Spray-drying technique was employed to fabricate nanoparticle-coated microparticles.
  • Diclofenac was used as the model drug, associated with silicon dioxide core.

Related Experiment Videos

  • Eudragit S100 and polymeric nanocapsules/nanospheres were utilized as gastric-resistant coatings.
  • In vitro drug release studies were conducted in buffered media at pH 1.2, 5.0, and 7.4.

    • Main Results:

    • The study demonstrated the technological feasibility of producing controlled nanoparticle-coated drug-loaded inorganic microparticles.
    • Formulations using Eudragit S100 exhibited adequate gastroresistance for hydrophilic diclofenac (salt form).
    • Hydrophobic diclofenac (acid form) formulations showed good gastroresistance when nanocapsules and triacetin were used.

    Conclusions:

    • Nanoparticle-coated inorganic microparticles can be successfully prepared using spray-drying for controlled drug delivery.
    • The choice of coating material (Eudragit S100 or nanocapsules/triacetin) is crucial for achieving desired gastroresistance based on drug properties.
    • This approach offers a viable strategy for developing gastro-resistant oral drug formulations.