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Inhibition of trypsin by the beta-amyloid protein precursor. A comparative study between transfected cells, human
A Delvaux1, L Van der Elst, J N Octave
1Laboratoire de Neurochimie, Université Catholique de Louvain, Brussels, Belgium.
FEBS Letters
|February 3, 1992
Abstract:
Soluble beta-amyloid protein precursors (beta-APPs) were studied in human brain and cerebrospinal fluid (CSF) after partial purification by ion exchange chromatography. Proteins were analysed in immunoblotting experiments using a monoclonal antibody directed against the N-terminal segment of the beta-APP 770, and by reverse enzymography. In the human brain and CSF, a protein which comigrates with the beta-APP 770 expressed by transfected CHO cells was able to inhibit trypsin.