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Updated: Aug 21, 2026

Synthesis of Hypervalent Iodonium Alkynyl Triflates for the Application of Generating Cyanocarbenes
Published on: September 8, 2013
Cobalt-mediated cyclotrimerisation of bis-alkynes and cyanamides
Llorente V R Boñaga1, Han-Cheng Zhang, Bruce E Maryanoff
1Drug Discovery, Johnson & Johnson Pharmaceutical Research & Development, Spring House, PA 19477-0776, USA.
Abstract:
CpCo(CO)2-mediated cyclotrimerisation of bis-alkynes and cyanamides provides multisubstituted 2-aminopyridines, including macrocyclic products, such as 22 (50% yield).
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