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Published on: February 28, 2019
[Analysis of p53 gene mutation in salivary adenoid cystic carcinoma.]
Dong-sheng Zhang1, Cui-rong Bian, Pei-yu Wang
1Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital, Shandong University, Jinan 250021, Shandong Province, China. ds63zhang@hotmail.com.
Purpose:
The purpose of this study was to investigate the occurrence of p53 gene mutation in salivary adenoid cystic carcinoma, the correlation between the gene and prognostic significance.
Methods:
A series of salivary adenoid cystic carcinoma were studied by polymerase chain reaction and single strand conformation polymorphism (PCR-SSCP) analysis to detect p53 mutation, respectively.
Results:
The result showed that p53 gene mutations in exon 5-8 were detected in 65.8% (25/38) of the salivary adenoid cystic carcinoma. The p53 gene mutation was related to tumor distant metastasis and tumor recurrence (P<0.05) but not related to pathological types, clinical stages (P>0.05).There was a significant correlation between p53 gene mutation and postoperative survival .
Conclusion:
It is suggested that p53 gene mutations were very common in salivary adenoid cystic carcinoma, and might be useful in screening progress and evaluating prognosis of patients.
