Related Experiment Video
Updated: Aug 21, 2026

Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with β-arrestin
Published on: December 23, 2010
Urine leukotriene B4 in familial Mediterranean fever
A G Bentancur1, N Naveh, J Lancri
1Emergency Medicine Department, Sheba Medical Center, Tel Hashomer, Israel.
Objective:
To determine urinary leukotriene B4 (LTB4) levels and their role in FMF:
Methods:
Urinary LTB4 levels were studied using a commercial ELISA kit in 12 FMF patients during abdominal attacks, and 20 FMF patients during remission.
Results:
Urinary LTB4 levels in FMF patients during attacks were comparable to those during remission, but higher than normal levels (p = 0.03).
Conclusions:
These findings suggest a persistent activation of the leukotriene pathway in FMF. Whether elevated LTB4 levels are the cause or the effect of inflammation is yet to be determined.
Related Concept Videos
Inflammatory Bowel Disease III: Crohn's Disease
Amebiasis
Inflammatory Bowel Disease II: Ulcerative Colitis
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
