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[Pertussis vaccine in adolescents and adults]

J Lévy1, B Swennen, Y Van Laethem

  • 1Services de Pédiatrie, CHU Saint-Pierre, Bruxelles.

Revue Medicale De Bruxelles
|November 2, 2004
PubMed

Insights

Despite high infant immunization rates, Bordetella pertussis (whooping cough) persists, causing severe illness in unvaccinated infants and prolonged cough in others. Limited vaccine protection duration necessitates updated strategies.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Vaccinology

Context:

  • Bordetella pertussis continues to circulate globally despite widespread infant immunization.
  • Severe pertussis infections occur in infants too young for vaccination.
  • Prolonged cough episodes are common in older children and adults due to waning immunity.

Purpose:

  • To discuss the ongoing challenge of pertussis (whooping cough) in industrialized nations.
  • To highlight the limitations of current vaccine-induced immunity duration.
  • To explore the role and indications of acellular pertussis vaccines in various age groups.

Summary:

  • High infant immunization rates have not eliminated Bordetella pertussis circulation.
  • Waning immunity from early childhood vaccination contributes to disease persistence.
  • Acellular pertussis vaccines offer potential for broader age group immunization, including adults.

Impact:

  • Improved understanding of pertussis epidemiology and vaccine effectiveness.
  • Informing public health strategies for pertussis control.
  • Guiding the implementation of updated vaccination schedules for enhanced population immunity.

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