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An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions
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Simultaneously monitoring gene expression kinetics and genetic noise in single cells by optical well arrays

Yina Kuang1, Israel Biran, David R Walt

  • 1Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, Massachusetts 02155, USA.

Analytical Chemistry
|November 2, 2004
PubMed

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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...