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Hydroxycarbazepine distribution in three postmortem cases.

Barry Levine1, Deborah Green-Johnson, Karla A Moore

  • 1Office of the Chief Medical Examiner, State of Maryland, 111 Penn Street, Baltimore, Maryland 21201, USA.

Journal of Analytical Toxicology
|November 2, 2004
PubMed
Summary
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Hydroxycarbazepine, the active metabolite of oxcarbazepine, was detected in biological samples from three cases. Medical examiners determined it was an incidental finding unrelated to the cause of death.

Area of Science:

  • Forensic Toxicology
  • Pharmacology

Background:

  • Oxcarbazepine is an anticonvulsant prodrug.
  • Hydroxycarbazepine is its active metabolite.
  • Accurate toxicological analysis is crucial in forensic investigations.

Observation:

  • Three cases involved the detection of hydroxycarbazepine in biological specimens.
  • Samples were analyzed by the Office of the Chief Medical Examiner.
  • Gas chromatography-nitrogen-phosphorus detection was utilized for quantitation.

Findings:

  • Hydroxycarbazepine was quantified in heart blood at concentrations of 34.6, 40.5, and 3.7 mg/L.
  • Peripheral blood concentrations in two cases were 36 and 4.1 mg/L.
  • The presence of hydroxycarbazepine was deemed incidental to the cause of death in all three cases.

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Implications:

  • This study highlights the importance of identifying active metabolites in forensic toxicology.
  • The findings contribute to the understanding of hydroxycarbazepine levels in post-mortem cases.
  • Establishes reference concentrations for hydroxycarbazepine in forensic contexts.