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Related Experiment Videos

Vesicle swelling regulates content expulsion during secretion.

Marie L Kelly1, Won Jin Cho, Aleksandar Jeremic

  • 1Department of Physiology, Wayne State University School of Medicine, 5245 Scott Hall, 540 E. Canfield, Detroit, MI 48201, USA.

Cell Biology International
|November 2, 2004
PubMed
Summary
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Secretory vesicle swelling is crucial for releasing cellular contents. This process enables cells to regulate the expulsion of intravesicular substances, explaining partially empty vesicles post-secretion.

Area of Science:

  • Cell Biology
  • Physiology

Background:

  • Secretion is a fundamental cellular process involving the release of substances.
  • The role of secretory vesicle swelling in secretion remains poorly understood.

Purpose of the Study:

  • To investigate the involvement and function of secretory vesicle swelling in live cells.
  • To elucidate the mechanism by which vesicle swelling influences the secretion process.

Main Methods:

  • Utilized pancreatic acinar cells and neuronal models for live-cell imaging.
  • Observed and analyzed secretory vesicle behavior during secretion.

Main Results:

  • Demonstrated secretory vesicle swelling in live pancreatic acinar cells and neurons.
  • Showed that vesicle swelling enhances fusion with the plasma membrane.

Related Experiment Videos

  • Found that swelling is essential for the expulsion of intravesicular contents.

    • Conclusions:

    • Secretory vesicle swelling is a key regulatory mechanism in cellular secretion.
    • The degree of swelling correlates with the amount of released content, allowing for regulated release.
    • This finding explains the observation of partially empty vesicles after secretion.