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Morning levels of fibrinogen in children with sleep-disordered breathing
A G Kaditis1, E I Alexopoulos, E Kalampouka
1Dept of Paediatrics, University of Thessaly School od Medicine, Larissa University Hospital, PO Box 1425, Larissa 41110, Greece. KADITIA@hotmail.com
Insights
Children with habitual snoring have higher fibrinogen levels, a cardiovascular risk marker. However, fibrinogen levels did not correlate with sleep-disordered breathing severity in these children.
Area of Science:
- Pediatric Sleep Medicine
- Cardiovascular Risk Factors
- Hemostasis
Background:
- Elevated fibrinogen is a known cardiovascular disease predictor in adults.
- Fibrinogen levels are linked to sleep-disordered breathing in adults.
- Cardiovascular risk factors differ between adults and children.
Purpose of the Study:
- To investigate the association between fibrinogen levels and sleep-disordered breathing in children.
- To compare fibrinogen levels in children with and without habitual snoring.
Main Methods:
- A case-control study involving children with and without habitual snoring.
- Polysomnography (sleep studies) performed on all snoring children.
- Measurement of morning fibrinogen levels and calculation of the apnoea-hypopnoea index (AHI).
Main Results:
- Children with habitual snoring exhibited higher fibrinogen values compared to non-snoring controls.
- Fibrinogen levels were similar between children with and without moderate-to-severe sleep-disordered breathing (AHI ≥ 5 vs. AHI < 5).
- No significant correlation was found between fibrinogen levels and AHI, respiratory movement/arousal index, or hemoglobin desaturation index.
Conclusions:
- Habitual snoring in children is associated with elevated fibrinogen levels.
- Fibrinogen levels in children are not directly associated with the severity of sleep-disordered breathing as measured by polysomnography indices.
Abstract:
Elevated fibrinogen level is a predictor of cardiovascular disease in adults, and it is associated with sleep-disordered breathing. Levels of fibrinogen in adults are affected by other co-existing cardiovascular risk factors, which are not usually present in children. To investigate the association between fibrinogen and sleep-disordered breathing, a case-control study was carried out in children with and without habitual snoring. All snoring children underwent polysomnography. Morning fibrinogen values in 30 children with snoring and an apnoea-hypopnoea index (AHI) > or =5 episodes x h(-1) (median (interquartile range) 318 mg x dL(-1) (290-374)) were similar to values in 61 children with snoring and an AHI <5 episodes x h(-1) (307 (269-346)). Both groups had higher fibrinogen values than those in 23 controls without snoring (271 mg x dL(-1) (244-294)). There was no correlation between fibrinogen values and AHI, respiratory movement/arousal index or haemoglobin desaturation index. In conclusion, fibrinogen values are higher in children with snoring than in controls, but there is no association between these values and polysomnography indices.
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