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A synthetic retinoid Am80 (tamibarotene) rescues the memory deficit caused by scopolamine in a passive avoidance
Koichi Shudo1, Hiroyuki Kagechika, Noriyuki Yamazaki
1Research Foundation Itsuu Laboratory, Tokyo, Japan. kshudo@itsuu.or.jp
Biological & Pharmaceutical Bulletin
|November 2, 2004
Abstract:
Memory deficit in rats treated with scopolamine was rescued by several synthetic retinoids, RAR-ligands (Am80, Am555S, Tp80) and an RXR-ligand (HX630). These results may have implications for the treatment of Alzheimer's disease, age-related dementia, Parkinson's disease, and other neurological disorders.
