Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelial cell alignment on cyclically-stretched silicone surfaces.

M Moretti1, A Prina-Mello, A J Reid

  • 1Centre for Bioengineering, Trinity College, Dublin, Ireland.

Journal of Materials Science. Materials in Medicine
|November 2, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-yield isolation and characterization of microvascular niche cells from human full-thickness skin biopsies.

Scientific reports·2026
Same author

Fermion-Selective Tests of New Physics with the Bound-Electron g Factor.

Physical review letters·2026
Same author

Baseline clinical profile of patients with obstructive hypertrophic cardiomyopathy in the Italian Mavacamten early access program.

International journal of cardiology·2026
Same author

Biofabrication of a 3D human skeletal muscle microenvironment to study the early steps of fibrosis.

Materials today. Bio·2025
Same author

Evaluation of the association between sex-linked genes and treatment response in lung cancer.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2025
Same author

g Factor of Boronlike Tin.

Physical review letters·2025
Same journal

Zinc-polydopamine nanozyme promotes mitochondrial biogenesis and alleviates inflammation and muscle atrophy during the perioperative period of surgery.

Journal of materials science. Materials in medicine·2026
Same journal

Immuno-instructive biomaterials for coronary artery disease and myocardial infarction repair.

Journal of materials science. Materials in medicine·2026
Same journal

Effect of topical nanoemulsion of minoxidil on animal hair growth: an in vivo study.

Journal of materials science. Materials in medicine·2026
Same journal

Selective cytotoxicity of zinc peroxide and tetrapodal zinc oxide micro-nanoparticles against breast cancer cells: synthesis, characterization, and therapeutic potential.

Journal of materials science. Materials in medicine·2026
Same journal

Progress and challenges of tantalum-containing biomaterials in regenerative medicine applications.

Journal of materials science. Materials in medicine·2026
Same journal

Synchronizing degradation with regeneration: a model-driven framework for designing biodegradable biomaterials in bone tissue engineering.

Journal of materials science. Materials in medicine·2026
See all related articles

Cyclic mechanical forces deform endothelial cells, causing them to reorient. This study shows substrate stretch alone alters cell morphology, impacting cardiovascular physiology.

Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Cardiovascular Physiology

Background:

  • Endothelial cells experience mechanical forces in vivo, crucial for cardiovascular health.
  • Cyclic forces like stretch and fluid shear induce cell deformation.
  • The impact of cyclic forces on endothelial cell morphology is not fully understood.

Purpose of the Study:

  • Investigate endothelial cell response to substrate deformation.
  • Understand how cyclic forces alter endothelial cell morphology.
  • Assess the role of stretch stimulus independent of fluid flow.

Main Methods:

  • Human umbilical vein endothelial cells (HUVEC) cultured on silicone strips.
  • Uni-axial cyclic stretching applied using a custom mechanical device.

Related Experiment Videos

  • Cell morphology changes observed under 10% deformation.

    • Main Results:

    • Endothelial cells reoriented perpendicular to the stretch direction within 4 hours.
    • Plasma-treated silicone supported cell adhesion comparable to collagen type I.
    • Stretch stimulus alone significantly affected endothelial cell morphology.

    Conclusions:

    • Substrate deformation alone can alter endothelial cell morphology.
    • Further research needed to compare substrate strain and fluid flow effects.
    • Findings contribute to understanding mechanical forces in cardiovascular physiology.