Subversion of phosphoinositide metabolism by intracellular bacterial pathogens
Javier Pizarro-Cerdá1, Pascale Cossart
1Unité des Interactions Bactéries-Cellules/Unité INSERM 604, Institut Pasteur, 75724 Paris Cedex 15, France. pizarroj@pasteur.fr
Abstract:
Phosphoinositides are short-lived lipids, whose production at specific membrane locations in the cell enables the tightly controlled recruitment or activation of diverse cellular effectors involved in processes such as cell motility or phagocytosis. Bacterial pathogens have evolved molecular mechanisms to subvert phosphoinositide metabolism in host cells, promoting (or blocking) their internalization into target tissues, and/or modifying the maturation fate of their proliferating compartments within the intracellular environment.
Related Concept Videos
Phosphoinositides and PIPs
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
Colonisation of Pathogens
Regulation of Bacterial Virulence
IP3/DAG Signaling Pathway
Intracellular Movement of Viruses and Bacteria
Gene Regulation in Microbial Communities: Quorum Sensing

