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Updated: Aug 15, 2026

Quantitative Analysis of Cell Edge Dynamics during Cell Spreading
Published on: May 22, 2021
The many faces of filamin: a versatile molecular scaffold for cell motility and signalling
Yuanyi Feng1, Christopher A Walsh
1Department of Neurology, Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, New Research Building Rm 266, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Abstract:
Filamins were discovered as the first family of non-muscle actin-binding protein. They are lage cytoplasmic proteins that cross-link cortical actin into a dynamic three-dimensional structure. Filamins have also been reported to interact with a large number of cellular proteins of great functional diversity, suggesting that they are unusually versatile signalling scaffolds. More recently, genetic mutations in filamin A and B have been reported to cause a wide range of human diseases, suggesting that different diseases highlight distinct filamin interactions.
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