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[Systemic corticoid application in combination with topical mitomycin or dexamethasone. Inhibition of wound healing
1Klinik und Poliklinik für Hals-, Nasen- und Ohrenkrankheiten, Kopf- und Hals-Chirurgie der Ernst-Moritz-Arndt-Universität Greifswald. H.Kaftan@web.de
Background:
The purpose of this study was to determine whether systemic glucocorticoid application, in combination with topical mitomycin or dexamethasone, prolongs the patency of a tympanic membrane perforation.
Method:
Bilateral myringotomies were performed on 24 rats. The 48 ears were separated into eight groups. Treatment with combined systemic and topical dexamethasone or mitomycin differed between these groups. After the first 2 weeks, the animals were checked weekly for a total of 12 weeks.
Results:
A combination of systemic and topical dexamethasone delayed tympanic membrane closure after myringotomy. Perforation size increased in all tympanic membranes treated with mitomycin plus systemic dexamethasone.
Conclusion:
Topical mitomycin plus systemic glucocorticoid may lead to a massive malfunction of tympanic membrane healing.
