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Variable atrioventricular block in systemic lupus erythematosus.

Sybille Liautaud1, Ahmed J Khan, Shireesha R Nalamasu

  • 1Division of Pulmonary and Critical Care, Department of Medicine, Mount Sinai School of Medicine, 164-04, 85th Avenue, Jamaica, NY 11432, USA. lsybille67@hotmail.com

Clinical Rheumatology
|November 2, 2004
PubMed
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Systemic lupus erythematosus can affect the heart, causing conduction abnormalities like atrioventricular block. These cardiac issues in lupus patients may resolve with corticosteroid treatment.

Area of Science:

  • Cardiology
  • Rheumatology
  • Immunology

Background:

  • Systemic lupus erythematosus (SLE) is an autoimmune disease affecting multiple organs.
  • Cardiac involvement in SLE is common, but conduction system disruption is less frequently reported.

Observation:

  • A 45-year-old asymptomatic woman with SLE presented with thrombocytopenia.
  • Electrocardiography revealed progressive atrioventricular block (AVB), from first-degree to Mobitz type I second-degree.

Findings:

  • The patient exhibited alternating first- and second-degree AVB over a 28-hour period.
  • Conduction abnormalities showed rapid progression from mild first-degree to significant first-degree and then second-degree AVB.
  • These transient cardiac conduction disturbances resolved following corticosteroid therapy.

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Implications:

  • This case highlights the potential for SLE to cause significant, albeit reversible, cardiac conduction abnormalities.
  • Early recognition and management of cardiac involvement in SLE are crucial.
  • Further research into the mechanisms of cardiac conduction system disruption in SLE is warranted.