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Updated: Aug 21, 2026

Chromosome Preparation From Cultured Cells
Published on: January 28, 2014
De novo complex chromosome rearrangement: a study of two patients
D G Melo1, J Huber, L R Giuliani
1Department of Genetics, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil.
Abstract:
Complex chromosome rearrangements (CCR) involving multiple breaks in two or more chromosomes are rare. We describe a girl with development delay and overgrowth who presents a nine-break apparently balanced de novo rearrangement involving chromosomes 1, 2, 3, 4 and 12, and a boy with developmental delay and seizures with a complex three-chromosome apparently balanced de novo rearrangement involving chromosomes 2, 7 and 13. The relationship between clinical abnormalities and apparently balanced rearrangements is discussed.
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