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Dihydrotestosterone is a peripheral paracrine hormone.

R Horton1

  • 1Department of Medicine, University of Southern California, Los Angeles 90033.

Journal of Andrology
|January 1, 1992
PubMed
Summary

Dihydrotestosterone (DHT) acts locally in tissues like skin and prostate. Its metabolite, 3 alpha androstanediol glucuronide (3 alpha diol G), is a better indicator of DHT formation in these target tissues than blood DHT levels.

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Area of Science:

  • Endocrinology
  • Androgen Metabolism
  • Dermatology

Background:

  • Dihydrotestosterone (DHT) is a key androgen mediating action in sexual tissues, primarily derived from testosterone (T) conversion.
  • Blood levels of DHT and its metabolite 3 alpha androstanediol (3 alpha diol) may not accurately reflect peripheral DHT formation.
  • DHT is increasingly recognized as a paracrine hormone, acting locally within target tissues.

Purpose of the Study:

  • To evaluate the reliability of circulating DHT and its metabolites as indicators of androgen action.
  • To identify the most effective marker for assessing DHT formation in peripheral tissues, particularly skin.
  • To explore the clinical utility of 3 alpha androstanediol glucuronide (3 alpha diol G) in various androgen-related conditions.

Main Methods:

  • Review of studies investigating DHT and its metabolite metabolism and levels.
  • Analysis of discrepancies between blood/urine levels and actual DHT formation.
  • Correlation of 3 alpha diol G levels with pubertal development and specific androgenic disorders.

Main Results:

  • Blood DHT and 3 alpha diol levels are not reliable indicators of total body DHT formation.
  • 3 alpha androstanediol glucuronide (3 alpha diol G) is a major DHT metabolite formed in the skin.
  • Elevated 3 alpha diol G levels are observed in hirsutism, acne, and adrenal disorders, correlating with androgenicity and treatment response.

Conclusions:

  • DHT should be considered a paracrine hormone with local action in target tissues.
  • 3 alpha androstanediol glucuronide (3 alpha diol G) is the most reliable marker for assessing DHT formation in skin and other target tissues.
  • 3 alpha diol G shows clinical utility in monitoring androgen-related conditions and therapeutic efficacy.

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