Related Experiment Video

Updated: Aug 7, 2026

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform
09:35

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform

Published on: July 16, 2016

Roles for bone-marrow-derived cells in beta-cell maintenance

Jeffery S Tessem1, James DeGregori

  • 1Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center at Fitzsimons, PO Box 6511, MS8101 Aurora, CO 80045, USA.

Trends in Molecular Medicine
|November 3, 2004
PubMed

Insights

Researchers are exploring adult bone marrow to boost beta-cell expansion for diabetes treatment. Studies in mice show marrow-derived cells may help maintain and increase beta-cells, offering potential therapeutic avenues.

Area of Science:

  • * Regenerative Medicine
  • * Endocrinology
  • * Diabetes Research

Background:

  • * Diabetes mellitus affects over 177 million people globally, with projections to double by 2030.
  • * Current therapeutic strategies prioritize increasing pancreatic beta-cell mass.
  • * Adult bone marrow is being investigated as a source for beta-cell regeneration.

Purpose of the Study:

  • * To investigate the potential of adult bone marrow-derived cells in promoting beta-cell expansion.
  • * To explore the mechanisms by which marrow-derived cells influence beta-cell maintenance and proliferation.
  • * To evaluate the therapeutic implications of these findings for diabetes treatment.

Main Methods:

  • * Studies conducted in murine models (mice).
  • * Induction of beta-cell expansion using adult bone marrow.
  • * Analysis of marrow-derived cell contribution to beta-cell populations.

Main Results:

  • * Bone marrow-derived cells demonstrated the capacity to contribute to beta-cell maintenance in mice.
  • * Evidence suggests these cells can promote endogenous beta-cell expansion.
  • * Potential for transdifferentiation of marrow-derived cells into functional beta-cells was observed.

Conclusions:

  • * Adult bone marrow represents a promising source for cellular therapies in diabetes.
  • * Marrow-derived cells can positively impact beta-cell function and number.
  • * These findings provide a foundation for developing novel therapeutic interventions for diabetes.

More Related Videos

Efficient Differentiation of Pluripotent Stem Cells to NKX6-1+ Pancreatic Progenitors09:23

Efficient Differentiation of Pluripotent Stem Cells to NKX6-1+ Pancreatic Progenitors

Published on: March 7, 2017

High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds12:32

High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds

Published on: January 23, 2018

Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
Maintenance of the ES Cell State01:14

Maintenance of the ES Cell State

The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...