Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

First- and midtrimester Down syndrome screening and detection.

Ray O Bahado-Singh¹, Sang-Joon Choi, Chih Chien Cheng

¹University of Cincinnati, Department of Obstetrics and Gynecology, 231 Albert Sabin Way ML0526, Cincinnati, OH 45267-0526, USA. bahadoro@ucmail.ac.edu

Clinics in Perinatology

|November 3, 2004

Summary

Screening for Down syndrome has greatly improved with new methods. Combining first- and second-trimester tests offers better accuracy but highlights the need for standardized approaches.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Influence of traditionality and modernity on public breastfeeding behaviors: a theory of planned behavior approach.

International breastfeeding journal·2025

Same author

Prenatal opioid exposure alters pain perception and increases long-term health risks in infants with neonatal opioid withdrawal syndrome.

Frontiers in pain research (Lausanne, Switzerland)·2025

Same author

Untargeted Metabolomic Biomarker Discovery for the Detection of Ectopic Pregnancy.

International journal of molecular sciences·2024

Same author

Prenatal opioid exposure significantly impacts placental protein kinase C (PKC) and drug transporters, leading to drug resistance and neonatal opioid withdrawal syndrome.

Frontiers in neuroscience·2024

Same author

Metabolomic prediction of severe maternal and newborn complications in preeclampsia.

Metabolomics : Official journal of the Metabolomic Society·2024

Same author

Placental cytochrome P450 methylomes in infants exposed to prenatal opioids: exploring the effects of neonatal opioid withdrawal syndrome on health horizons.

Frontiers in genetics·2024

Area of Science:

Prenatal diagnostics
Genetics
Maternal-fetal medicine

Background:

Down syndrome detection has seen significant advancements over the past 20 years.
Current screening methods include first-trimester screening and mid-trimester urine screening.

Purpose of the Study:

To review the progress in Down syndrome detection.
To address the challenges posed by multiple screening algorithms.

Main Methods:

Review of widely practiced first-trimester screening.
Evaluation of mid-trimester urine screening.
Analysis of combined first- and second-trimester screening approaches.

Main Results:

First-trimester screening is widely practiced and effective.

Related Experiment Videos

Mid-trimester urine screening offers additional diagnostic capabilities.

Combining screening across trimesters enhances fetal Down syndrome discrimination.

Conclusions:

Recent screening combinations improve Down syndrome detection accuracy.
The proliferation of algorithms risks patient and practitioner confusion.
A consensus on screening methods is urgently needed for clarity and effective healthcare planning.