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[Thyroid dysfunction after haematopoietic stem cell transplantation during childhood]

C Curtillet1, P Cuadras, E Dore

  • 1Service hématologie pédiatrique du professeur Michel, hôpital Timone-Enfants, 264, rue Saint-Pierre, 13385 Marseille cedex 05, France. Catherine.Curtillet@mail.ap-hm.fr

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|November 3, 2004
PubMed

Insights

Children undergoing bone marrow transplants face a significant risk of developing hypothyroidism, particularly after total body irradiation (TBI). Younger age increases this risk, highlighting the need for vigilant thyroid monitoring post-transplant.

Area of Science:

  • Pediatric Endocrinology
  • Hematology/Oncology
  • Transplantation Medicine

Context:

  • Bone marrow transplantation (BMT) is a critical treatment for various pediatric diseases.
  • Thyroid dysfunction is a known complication following BMT, but risk factors require further elucidation.
  • Conditioning regimens, including total body irradiation (TBI) and chemotherapy, can impact endocrine function.

Purpose:

  • To assess the incidence and identify risk factors for thyroid dysfunction in pediatric BMT recipients.
  • To compare the risk of hypothyroidism between different conditioning regimens (TBI vs. Busulphan).
  • To investigate the influence of age, gender, primary disease, and graft-versus-host disease on thyroid function.

Summary:

  • This study evaluated 79 children post-BMT, finding a 36% six-year probability of hypothyroidism.
  • Patients receiving TBI had a significantly higher risk (49%) compared to those treated with Busulphan (9%).
  • Younger age (<7.7 years) was identified as a significant risk factor for hypothyroidism in the TBI group.

Impact:

  • Highlights the substantial risk of hypothyroidism in pediatric BMT survivors, especially post-TBI.
  • Identifies younger age as a novel risk factor, necessitating targeted monitoring.
  • Recommends long-term thyroid function surveillance for all BMT patients, irrespective of conditioning regimen.
Abstract

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