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Age, alcohol consumption, and all-cause mortality.

Volker Arndt1, Dietrich Rothenbacher, Reinhard Krauledat

  • 1German Centre for Research on Ageing, Department of Epidemiology, Heidelberg, Germany. arndt@dzfa.uni-heidelberg.de

Annals of Epidemiology
|November 3, 2004
PubMed
Summary

Moderate alcohol consumption may lower mortality in middle-aged men, but this benefit is not seen in younger adults. For men aged 25-34, increased alcohol intake correlates with higher all-cause mortality.

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Area of Science:

  • Occupational Health
  • Epidemiology
  • Public Health

Background:

  • Previous epidemiological studies suggest moderate alcohol consumption is linked to lower all-cause mortality in middle-aged men.
  • However, the association between alcohol intake and mortality in younger adults remains unclear.

Purpose of the Study:

  • To investigate the age-specific association between alcohol consumption and all-cause mortality.
  • To determine if the protective effects of moderate alcohol intake extend to younger adult populations.

Main Methods:

  • A cohort study of 19,943 male employees in the German construction industry (ages 25-64) was conducted.
  • Alcohol consumption was self-reported and validated with biological markers.
  • Follow-up for vital status occurred over an average of 10 years, with proportional hazard regression analysis accounting for covariates.

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Main Results:

  • A J/U-shaped association between alcohol consumption and all-cause mortality was observed only in men aged 35 and above.
  • Younger men (aged 25-34) exhibited a linear, positive dose-response relationship between alcohol intake and mortality (p-trend=0.02).

Conclusions:

  • The findings indicate that the relationship between alcohol consumption and mortality varies significantly by age.
  • Health recommendations concerning alcohol should consider age-specific risks and benefits.