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Updated: Aug 21, 2026
A Murine Model of Hyperlipidemia-Induced Heart Failure with Preserved Ejection Fraction
Published on: March 29, 2024
Murine models for the study of congestive heart failure: Implications for understanding molecular mechanisms and for
Qing-Dong Wang1, Mohammad Bohlooly-Y, Mohammad Bohlooly
1Integrative Pharmacology, AstraZeneca R&D Mölndal, 431 83 Mölndal, Sweden. qing-dong.wang@astrazeneca.com
Abstract:
Congestive heart failure (CHF) is a complex illness of diverse aetiology. Despite the current multiple therapies, the prognosis for CHF patients remains poor, and new therapeutic targets need to be identified. With the advent of the genetic era, the mouse has become an increasingly valuable animal species in experimental CHF research. A large number of murine models of cardiac hypertrophy and CHF have been created by genetic engineering. Meanwhile, traditional CHF models created by coronary artery ligation, cardiac pressure, or volume overload have been adapted to mice. The present review categorizes and highlights the value of these murine models of cardiac hypertrophy and CHF. These models, combined with sophisticated physiological measurements of cardiac haemodynamics, are expected to yield more and valuable information regarding the molecular mechanisms of CHF and aid in the discovery of novel therapeutic targets.
Insights
Murine models are crucial for studying congestive heart failure (CHF) and cardiac hypertrophy. These models, combined with advanced measurements, help identify new therapeutic targets for poor-prognosis CHF patients.
Area of Science:
- Cardiovascular Research
- Translational Medicine
- Animal Models
Background:
- Congestive heart failure (CHF) presents a complex clinical challenge with a poor prognosis despite existing therapies.
- Identifying novel therapeutic targets is essential for improving outcomes in CHF patients.
Purpose of the Study:
- To review and categorize existing murine models for cardiac hypertrophy and CHF.
- To highlight the utility of these models in advancing CHF research and therapeutic target discovery.
Main Methods:
- Genetic engineering to create novel murine models of cardiac hypertrophy and CHF.
- Adaptation of traditional CHF models (e.g., coronary artery ligation, pressure/volume overload) to mice.
- Utilizing sophisticated physiological measurements of cardiac hemodynamics.
Main Results:
- A comprehensive categorization of various murine models relevant to CHF and cardiac hypertrophy.
- Demonstration of the increasing value of genetically engineered and adapted traditional models in mice.
- Integration of hemodynamic measurements with these models provides valuable data.
Conclusions:
- Murine models are indispensable tools for investigating the molecular mechanisms underlying CHF.
- These models, coupled with advanced physiological assessments, are pivotal for discovering new therapeutic strategies for CHF.
- Further research using these models is expected to significantly improve the prognosis for CHF patients.
