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Alterations in renal function in psoriasis patients treated with cyclosporine, 5 mg/kg/day
D J Margolis1, C Guzzo, J Johnson
1Department of Dermatology, Hospital of the University of Pennsylvania.
Background:
Cyclosporine has been used to treat a variety of cutaneous and immune-mediated diseases. Nephrotoxicity is the most common major adverse side effect.
Objective:
The study was designed to investigate the frequency of alterations in serum creatinine in patients with psoriasis receiving 5 mg/kg/day of cyclosporine.
Methods:
Sixteen patients with severe refractory psoriasis received cyclosporine, 5 mg/kg/day, for 12 weeks. Serum creatinine was evaluated with respect to each patient's baseline.
Results:
Serum creatinine levels remained in the normal range, but 10 of 16 patients had a 30% elevation and 5 of 16 patients had a 50% elevation of serum creatinine compared with the patient's baseline value.
Conclusion:
These results indicate that a significant elevation in serum creatinine occurs in many patients who receive cyclosporine for psoriasis.