Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dopamine receptor signaling.

Kim A Neve1, Jeremy K Seamans, Heather Trantham-Davidson

  • 1Veterans Affairs Medical Center and Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA. nevek@ohsu.edu

Journal of Receptor and Signal Transduction Research
|November 4, 2004
PubMed
Summary

Dopamine receptors D1-like and D2-like signal through distinct G proteins, influencing cellular activity. Protein interactions also critically regulate these dopamine receptor pathways.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dopamine Responses in Medial Frontal Cortex Are More Consistent with a Generalized Arousal Signal Than Signed Reward Prediction Errors.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Mice carrying the human dopamine D2 receptor pathogenic mutation p.Met374Arg exhibit hyperactivity and aberrant D2 receptor function.

Molecular pharmacology·2025
Same author

Temporal information in the anterior cingulate cortex relates to accumulated experiences.

Current biology : CB·2024
Same author

Neural basis of cognitive control signals in anterior cingulate cortex during delay discounting.

bioRxiv : the preprint server for biology·2024
Same author

Comparison of the function of two novel human dopamine D2 receptor variants identifies a likely mechanism for their pathogenicity.

Biochemical pharmacology·2024
Same author

Reconfiguration of Behavioral Signals in the Anterior Cingulate Cortex Based on Emotional State.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2024

Area of Science:

  • Neuroscience
  • Molecular Pharmacology

Background:

  • Dopamine receptors are classified into D1-like (D1, D5) and D2-like (D2, D3, D4) families.
  • Both classes share signaling properties but exhibit subtype-specific differences.

Purpose of the Study:

  • To elucidate the distinct signaling mechanisms of D1-like and D2-like dopamine receptors.
  • To highlight the roles of G proteins and protein-protein interactions in dopamine receptor regulation.

Main Methods:

  • Review of established signaling pathways for dopamine receptor classes.
  • Analysis of G protein (Galphas, Galphaolf, Galphai, Galphao) involvement.
  • Consideration of downstream effectors like adenylate cyclase, protein kinases, and ion channels.
  • Examination of protein:protein interactions, including receptor oligomerization and scaffolding proteins.

Related Experiment Videos

Main Results:

  • D1-like receptors primarily signal via Galphas/Galphaolf, activating adenylate cyclase and protein kinase A, leading to DARPP-32 phosphorylation.
  • D2-like receptors signal through Galphai/Galphao, modulating effectors via Galpha subunits and liberated Gbetagamma subunits.
  • Both classes exhibit cAMP-independent signaling, including calcium mobilization for D1-like receptors.
  • Protein interactions, such as receptor oligomerization, are crucial for fine-tuning dopamine receptor signaling.

Conclusions:

  • Dopamine receptor signaling is complex, involving distinct G protein pathways and downstream effectors for D1-like and D2-like classes.
  • G protein subunit diversity (Galpha vs. Gbetagamma) dictates effector engagement.
  • Non-G protein interactions are essential for comprehensive regulation of dopamine receptor function.