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Correlation between age and allergens in pediatric atopic dermatitis

I-Jen Wang1, Yu-Tsan Lin, Yao-Hsu Yang

  • 1Department of Pediatrics, Taipei Hospital, Department of Health, Taipei, Taiwan.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|November 4, 2004
PubMed

Insights

In children with atopic dermatitis (AD), food allergens are primary triggers in early life. As children age, environmental aeroallergens become more significant, potentially leading to respiratory symptoms.

Area of Science:

  • Pediatric Allergy and Immunology
  • Dermatology
  • Clinical Immunology

Background:

  • Atopic dermatitis (AD) is increasingly linked to aeroallergens.
  • Sensitization patterns to food and aeroallergens in pediatric AD require further investigation.

Purpose of the Study:

  • To investigate the relationship between age and allergen sensitization in children diagnosed with atopic dermatitis (AD).

Main Methods:

  • Retrospective cross-sectional study of 262 children (0-16 years) with AD.
  • Analysis of food and aeroallergen sensitization using CAP-FEIA test across three age groups: <2, 2-5, and >5 years.
  • Statistical analysis included linear and logistic regression.

Main Results:

  • In children under 2 years, AD correlated with food allergens.
  • In children aged 2-5 years, both food and aeroallergens were significant.
  • In children over 5 years, elevated aeroallergen-specific IgE was observed (P < .02), with age positively correlating with aeroallergen sensitization (P < .04).

Conclusions:

  • Food allergens are likely the primary drivers of AD in infants.
  • The influence of environmental aeroallergens increases with age in pediatric AD.
  • Aeroallergen sensitization may be linked to the development of respiratory symptoms in the atopic state.
Abstract

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