[Acute intoxication with fenspiride]
Zygmunt Chodorowski1, Jacek Sein Anand, Roman Korolkiewicz
1I Klinika Chorób Wewnetrznych i Ostrych Zatruć, Akademii Medycznej w Gdańsku. jsanand@amedec.amg.gda.pl
Unlabelled:
According to the best of our knowledge this is the first publication in medical literature about the acute intoxication with fenspiride. The two cases of a young female patients, intoxicated with Eurespal, were described. The orthostatic hypotonia with the blood pressure about 105-115/70 mm Hg in the horizontal position and 70-80/40 mm Hg in the sitting position was dominating. The heart rate was 100-110/min. when lying and 130-140/min. when sitting. The main symptoms were probably caused by inhibition of alpha1 adrenergic receptors.
Conclusion:
Main clinical manifestations make us reconsider the opinion about safety of fenspiride especially after acute intoxication.
Related Concept Videos
Toxidromes: Clinical Features
Desensitization and Tachyphylaxis
Several...
Drug toxicity: Idiosyncratic Reactions
Drug Toxicity: Risk factors
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Drug Toxicity: Allergic Reactions

