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[Acute intoxication with fenspiride].

Zygmunt Chodorowski1, Jacek Sein Anand, Roman Korolkiewicz

  • 1I Klinika Chorób Wewnetrznych i Ostrych Zatruć, Akademii Medycznej w Gdańsku. jsanand@amedec.amg.gda.pl

Przeglad Lekarski
|November 4, 2004
PubMed
Summary

This study details two cases of acute fenspiride (Eurespal) intoxication in young women. The primary symptoms included significant orthostatic hypotension and tachycardia, likely due to alpha1 adrenergic receptor inhibition.

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Area of Science:

  • Pharmacology
  • Toxicology
  • Internal Medicine

Background:

  • Fenspiride, commonly marketed as Eurespal, is a medication used for respiratory symptoms.
  • Acute intoxication cases are not well-documented in medical literature.
  • Understanding the toxicological profile of fenspiride is crucial for patient safety.

Observation:

  • Two young female patients presented with acute intoxication after ingesting fenspiride.
  • Dominant symptoms included severe orthostatic hypotension (significant blood pressure drop upon sitting) and tachycardia (rapid heart rate).
  • Blood pressure dropped from 105-115/70 mm Hg supine to 70-80/40 mm Hg sitting.
  • Heart rate increased from 100-110/min supine to 130-140/min sitting.

Findings:

  • The clinical manifestations suggest a mechanism involving the inhibition of alpha1 adrenergic receptors.
  • This is the first reported series of acute fenspiride intoxication in the medical literature.
  • The observed symptoms highlight potential cardiovascular effects of fenspiride overdose.

Implications:

  • These findings necessitate a re-evaluation of fenspiride's safety profile, particularly in cases of acute overdose.
  • Clinicians should be aware of the potential for significant hemodynamic instability.
  • This case series underscores the importance of monitoring vital signs in patients with suspected fenspiride intoxication.

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