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[Acute oral suicidal intoxication with captan--a case report].
Zygmunt Chodorowski1, Jacek Sein Anand, Wojciech Waldman
1I Klinika Chorób Wewnetrznych i Ostrych Zatruć, Akademii Medycznej w Gdańsku.
Przeglad Lekarski
|November 4, 2004
Summary
This case study details acute captan intoxication in a young woman, highlighting potential cardiotoxic effects. The findings suggest captan exposure may impact cardiac function, warranting further investigation.
Area of Science:
- Toxicology
- Cardiology
- Clinical Medicine
Background:
- Captan is a widely used fungicide with limited documented cases of acute human intoxication.
- Understanding the toxicological profile of captan is crucial for clinical management and public health.
Observation:
- A 22-year-old female presented with nausea, weakness, numbness, and substernal pain following a 5.0 g captan ingestion.
- Initial vital signs were stable, but laboratory tests revealed elevated white blood cell count and creatine kinase activity.
- Electrocardiogram (ECG) showed transient T-segment inversions in anterior leads (V1-V4).
Findings:
- The patient's symptoms and laboratory findings, particularly elevated creatine kinase and ECG abnormalities, suggest potential cardiotoxicity from acute captan exposure.
- Echocardiograms performed on the 4th and 120th days post-intoxication showed no persistent cardiac structural changes, with preserved ejection fraction (EF) of 70%.
Implications:
- This case underscores the potential for captan to induce acute cardiotoxic effects, even without long-term cardiac damage.
- Further research into captan's mechanisms of cardiotoxicity and dose-response relationships in humans is warranted.
- Clinicians should consider captan poisoning in cases of acute intoxication with compatible cardiac symptoms.