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Published on: December 8, 2023
[Endoscopic treatment of vesicoureteral reflux]
Boris Chertin1, Alon Fridmans, Dmitry Koulikov
1Department of Urology, Shaare Zedek Medical Center, Jerusalem, Israel. bchertin@yahoo.com
Insights
Endoscopic subureteral injection offers an effective outpatient treatment for pediatric vesicoureteral reflux (VUR). Polytetrafluoroethylene remains reliable, while Deflux shows promise with no observed migration.
Area of Science:
- Pediatric Urology
- Minimally Invasive Surgery
- Biomaterials Science
Context:
- Vesicoureteral reflux (VUR) in children often requires intervention.
- Long-term antibiotic prophylaxis and surgery are traditional treatments.
- Endoscopic subureteral injection presents a less invasive alternative.
Purpose:
- To review worldwide data on endoscopic treatment of VUR.
- To compare the effectiveness of different tissue-augmenting substances.
- To evaluate long-term outcomes of endoscopic VUR treatment.
Summary:
- Polytetrafluoroethylene (Teflon) is a highly effective and reliable injectable material for endoscopic VUR treatment.
- Dextranomer/hyaluronic acid copolymer (Deflux) is a promising new substance with comparable efficacy to Teflon and no evidence of migration.
- Endoscopic subureteral injection is a safe, effective, and minimally invasive outpatient procedure for pediatric VUR.
Impact:
- Provides a less invasive treatment option for pediatric VUR.
- Offers an alternative to long-term antibiotic use and surgery.
- Highlights the efficacy and safety of endoscopic VUR treatments.
Objectives:
Endoscopic subureteral injection of tissue-augmenting substances, a 15-minute outpatient procedure has become an alternative to long-term antibiotic prophylaxis and surgical intervention in the treatment of vesicoureteral reflux (VUR) in children.
Materials And Methods:
We searched MEDLINE using the words: vesicoureteral reflux, treatment, the long-term results of endoscopic treatment of reflux. We summarized the worldwide data regarding endoscopic treatment of VUR using various tissue-augmenting substances presently available.
Results:
In terms of effectiveness and long-term successful results, polytetrafluoroethylene is still the most reliable injectable material for the endoscopic treatment of VUR. However, Dextranomer/hyaluronic acid copolymer (Deflux) is a new promising tissue augmenting substance which might be able to replace Teflon in the endoscopic treatment of reflux in terms of a similar to Teflon reflux cessation rate and exhibiting no evidence of migration.
Conclusion:
Endoscopic subureteral polytetrafluoroethylene injection is a simple and effective outpatient procedure for in the treatment of vesicoureteral reflux. No long-term morbidity was observed in our patients with small amounts of injectable polytetrafluoroethylene.
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