Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structural neural networks subserving oculomotor function in first-episode schizophrenia.

Manjinder S Bagary1, Samuel B Hutton, Mark R Symms

  • 1Institute of Neurology, University College London, Queens Square, London WC1N 3BG, United Kingdom.

Biological Psychiatry
|November 4, 2004
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bullying victimization and brain development: a longitudinal structural magnetic resonance imaging study from adolescence to early adulthood.

Translational psychiatry·2026
Same author

Digital Twin Brain simulation and manipulation of a functional brain network underlying mental illness.

bioRxiv : the preprint server for biology·2026
Same author

Optimal Deep Brain Stimulation Locations for Gilles de la Tourette Syndrome.

medRxiv : the preprint server for health sciences·2026
Same author

Characterising a stress-sensitive default mode network (DMN) deficit in major psychiatric disorders.

Communications biology·2026
Same author

Bullying Victimization and Brain Development: A Longitudinal Structural Magnetic Resonance Imaging Study from Adolescence to Early Adulthood.

bioRxiv : the preprint server for biology·2026
Same author

The Sex-Dependent Relationship Between Amygdala Activation and Depressive Symptoms With Problematic Drinking.

Biological psychiatry·2026

Abnormal eye movements in schizophrenia, like smooth pursuit and antisaccade errors, are linked to specific brain structure differences. This study used MRI to identify these neuropathological correlates in first-episode schizophrenia patients.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Neuroimaging

Background:

  • Oculomotor abnormalities, including smooth pursuit and antisaccade deficits, are recognized features of schizophrenia.
  • The underlying neuropathological basis for these eye movement abnormalities remains incompletely understood.

Purpose of the Study:

  • To investigate the relationship between oculomotor control deficits and brain structural alterations in first-episode schizophrenia.
  • To identify specific neuropathological correlates of smooth pursuit and antisaccade abnormalities using advanced neuroimaging techniques.

Main Methods:

  • Utilized statistical parametric mapping to analyze brain structure in 27 first-episode schizophrenia patients.
  • Employed conventional volumetric magnetic resonance imaging (MRI) and magnetization transfer ratio (MTR) for detailed tissue characterization.

Related Experiment Videos

Main Results:

  • Smooth pursuit dysfunction correlated with reduced MTR in brain regions, notably the right prefrontal cortex.
  • Antisaccade errors were associated with gray matter volume reductions in the right medial superior frontal cortex, but not with MTR.

Conclusions:

  • Specific structural brain abnormalities are demonstrably linked to abnormal eye movements in schizophrenia.
  • Findings suggest distinct neurobiological underpinnings for smooth pursuit and antisaccade deficits in early schizophrenia.