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Published on: December 2, 2015
Association analysis of FEZ1 variants with schizophrenia in Japanese cohorts
Kazuo Yamada1, Kazuhiko Nakamura, Yoshio Minabe
1RIKEN Brain Science Institute, Laboratory for Molecular Psychiatry, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Background:
DISC1 has been suggested as a causative gene for psychoses in a large Scottish family. We recently identified FEZ1 as an interacting partner for DISC1. To investigate the role of FEZ1 in schizophrenia and bipolar disorder, case-control association analyses were conducted in Japanese cohorts.
Methods:
We performed a mutation screen of the FEZ1 gene and detected 15 polymorphisms. Additional data on informative polymorphisms were obtained from public databases. Eight single nucleotide polymorphisms (SNPs) were analyzed in 119 bipolar disorder and 360 schizophrenic patients and age- and gender-matched control subjects. All genotypes were determined with the TaqMan assay, and selected samples were confirmed by sequencing.
Results:
Conclusions:
A modest association between FEZ1 and schizophrenia suggests that this gene and the DISC1-mediated molecular pathway might play roles in the development of schizophrenia, with FEZ1 affecting only a small subset of Japanese schizophrenia patients.
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