Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mapping in the atrioventricular junction.

B J Scherlag1, A Munsif, E Patterson

  • 1Department of Veterans Affairs Medical Center Research Service, Oklahoma City, Oklahoma.

Journal of Electrocardiology
|January 1, 1992
PubMed
Summary

Ectopic conduction, an abnormal heart rhythm, occurs when electrical signals bypass the normal pathway. This study induced and mapped this phenomenon in dogs, revealing its electrocardiogram (ECG) signature.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oral Burden of Sjögren Disease: A Systematic Review and Meta-analysis.

Journal of dental research·2026
Same author

[Ferritinemia, a complex marker of iron metabolism].

Revue medicale de Liege·2021
Same author

Integrated twin-screw wet granulation, continuous vibrational fluid drying and milling: A fully continuous powder to granule line.

International journal of pharmaceutics·2020
Same author

Effectiveness of the Gerundium Youth Educating Program in Hungary.

Transplantation proceedings·2019
Same author

Next-generation sequencing identifies novel mitochondrial variants in pituitary adenomas.

Journal of endocrinological investigation·2019
Same author

[The Patient Blood Management].

Revue medicale de Liege·2018

Area of Science:

  • Cardiology
  • Electrophysiology
  • Cardiac Anatomy

Background:

  • Ectopic conduction involves premature cardiac impulse exit from the specialized conduction system.
  • This occurs across a damaged Purkinje-ventricular muscle interface, leading to anomalous atrioventricular (AV) conduction.

Purpose of the Study:

  • To investigate the mechanisms and electrocardiogram (ECG) manifestations of ectopic conduction.
  • To induce and map ectopic conduction in a canine model.

Main Methods:

  • Induction of ectopic conduction via lidocaine injection or ischemic damage to the AV junction in dog hearts.
  • Utilized a multi-electrode plaque for mapping cardiac activation sequences.
  • Employed microelectrode studies and in vivo subthreshold stimulation (STS) to simulate electrotonic potentials.

Related Experiment Videos

Main Results:

  • ECG changes included loss of initial forces and replacement of Q waves with delta waves.
  • Mapped activation patterns showed reversal after His bundle damage.
  • In vitro and in vivo studies demonstrated subthreshold potentials mediating Purkinje-to-muscle connection.

Conclusions:

  • Ectopic conduction can be reliably induced and mapped in a canine model.
  • Subthreshold potentials play a crucial role in mediating ectopic conduction.
  • ECG findings like delta waves are characteristic of this anomalous conduction.