Related Experiment Video
Updated: Aug 21, 2026

Quantification of Endothelial Fatty Acid Uptake using Fluorescent Fatty Acid Analogs
Published on: August 15, 2025
Role of FATP in parenchymal cell fatty acid uptake
Jürgen Pohl1, Axel Ring, Thomas Hermann
1Department of Gastroenterology and Hepatology, University of Heidelberg, Germany.
Abstract:
Long-chain fatty acids (LCFAs) represent key metabolites for energy generation and storage. Transport and metabolism of LCFA are believed to be regulated by membrane-associated proteins that bind and transport LCFA. Identifying the postulated fatty acid transporters is of considerable interest since altered fatty acid uptake has been implicated in disease such as insulin resistance and obesity. Recently, a family of membrane associated proteins, termed fatty acid transport proteins (FATPs), have been described that enhance uptake of LCFAs. Until today, six members of this family, designated FATP1-6, have been characterized. This review will focus on FATP structure, expression patterns, regulation, mechanism of transport and clinical implications.
Related Concept Videos
Overview of Fatty Acid Metabolism
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Fats as Energy Storage Molecules
Fats as Energy Storage Molecules
Carrier-Mediated Transport
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
Lipids as Anchors
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains the...
Receptor-mediated Endocytosis
