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Published on: January 4, 2018
Leptin acts peripherally to limit meal-induced increases in plasma insulin concentrations in mice: a brief
Anahita M Mistry1, Andrew G Swick, Dale R Romsos
1Department of Nutrition, Food, and Exercise Science, Florida State University, Tallahassee, FL 32306-1493, USA. amistry@garnet.acns.fsu.edu.
Abstract:
Leptin inhibits food intake and lowers plasma insulin concentrations. This study was designed to determine whether leptin acts independent of food-intake regulation to affect meal-induced increases in plasma insulin concentrations. Leptin-deficient, Lep(ob)/Lep(ob) mice were administered 1 microg leptin intracerebroventricularly (ICV) or intraperitoneally. Food intake and plasma insulin concentrations of mice administered leptin ICV before a meal were lower, as expected, than were intakes and plasma insulin concentrations of mice administered vehicle ICV. However when food intake was controlled, meal-induced increases in plasma insulin were unaffected by ICV administration of leptin. Intraperitoneal administration of 1 microg leptin before a meal lowered meal-induced increases in plasma insulin concentrations without influencing the size of the meal. We conclude that plasma leptin concentrations can affect meal-induced insulin secretion independent of the central nervous system actions of leptin associated with food-intake regulation.
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