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Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
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Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

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Increase in serum ionized calcium during diffusive dialysis does not affect left ventricular diastolic function

Eric H Y Ie1, Wim B Vletter, Folkert J ten Cate

  • 1Department of Medicine, Erasmus MC, Rotterdam, The Netherlands. e.ie@erasmusmc.nl

Blood Purification
|November 4, 2004
PubMed

Insights

Increased serum calcium during hemodialysis (HD) does not impair left ventricular (LV) diastolic function. Doppler measurements are influenced by preload, not serum calcium levels, during HD without ultrafiltration (UF).

Area of Science:

  • Nephrology
  • Cardiology
  • Physiology

Background:

  • Elevated serum calcium during hemodialysis (HD) may negatively impact left ventricular (LV) relaxation.
  • Assessing LV diastolic function in dialysis patients is challenging due to the preload dependency of Doppler measurements.

Purpose of the Study:

  • To investigate the effect of HD without ultrafiltration (UF) on Doppler-assessed LV diastolic function parameters.
  • To determine if increased serum calcium levels during HD alter LV diastolic function.

Main Methods:

  • Ten patients undergoing HD were studied before and after 1 hour of HD without UF.
  • Transmitral E and A velocities, and mitral annulus e and a velocities were measured.
  • Serum calcium levels were monitored, and dialysate calcium was maintained at 1.75 mmol/l.

Main Results:

  • Serum calcium levels increased significantly after 1 hour of HD without UF (p = 0.002).
  • Despite the rise in serum calcium, Doppler parameters of LV diastolic function (E/A and e/a ratios) showed no significant change.
  • The study found no correlation between increased serum calcium and alterations in LV diastolic function parameters.

Conclusions:

  • An increase in serum calcium during hemodialysis without ultrafiltration does not adversely affect Doppler-assessed left ventricular diastolic function.
  • Changes in LV diastolic function parameters observed during combined HD and UF are primarily related to preload alterations, not serum calcium levels.

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