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Related Experiment Videos

Prolonged evolution of a lentigo maligna.

Caroline Bevona1, Jessica Fewkes, Vincent Liu

  • 1Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

Journal of the American Academy of Dermatology
|November 4, 2004
PubMed
Summary
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Lentigo maligna (LM), a melanoma precursor, can persist and transform into lentigo maligna melanoma (LMM) over decades. This case highlights LM recurrence and progression even after multiple treatments and within a skin graft.

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Lentigo maligna (LM) is an intraepidermal melanocytic proliferation.
  • LM can precede the development of invasive lentigo maligna melanoma (LMM).
  • LM has a known propensity for local recurrence post-treatment.

Observation:

  • A patient presented with persistent lentigo maligna on the left cheek.
  • The lesion underwent multiple excisions over approximately 30 years.
  • The persistent LM eventually transformed into a partially amelanotic lentigo maligna melanoma.

Findings:

  • The lentigo maligna melanoma recurred at the border of a prior skin graft.
  • The melanoma subsequently invaded the previously grafted skin.
  • This case demonstrates a rare, prolonged course of LM with late malignant transformation and complex recurrence.

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Implications:

  • Highlights the challenges in completely eradicating lentigo maligna.
  • Suggests the need for long-term surveillance of treated LM lesions.
  • Underscores the potential for melanoma to arise and recur in challenging locations, including grafted skin.