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Updated: Aug 21, 2026
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
A new immune-competent animal model of mucosally derived squamous cell carcinoma
Hamid R Djalilian1, Khashayar Lessan, Vahid Grami
1Department of Otolaryngology, University of Minnesota, Minneapolis, MN, USA.
Objectives:
To develop an immune-competent animal model for mucosally derived squamous cell carcinoma (SCCA).
Study Design:
Fifteen Fischer 344 rats were inoculated with 1, 2, 5, 10, or 20 x 10(6) FAT7 cells in their flanks. The animals were observed for tumor growth and metastasis.
Results:
All animals developed tumors that grew exponentially. Pulmonary metastases developed in all animals and 13% developed lymph node metastases.
Conclusion:
The FAT7 flank tumor in Fischer 344 rats is a new animal model that closely resembles the behavior of human mucosal head and neck cancer.
Significance:
The existence of an immune-competent, mucosally derived, and reliable animal model of SCCA that somewhat resembles human head and neck SCCA gives the opportunity to perform immune-modulating experiments on head and neck cancer in these animals.
Ebm Rating:
B-3.
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