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Related Experiment Videos

Regulated nucleosome mobility and the histone code.

Michael S Cosgrove1, Jef D Boeke, Cynthia Wolberger

  • 1Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, 733 North Broadway Street, Baltimore, Maryland 21205, USA.

Nature Structural & Molecular Biology
|November 4, 2004
PubMed
Summary
This summary is machine-generated.

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New histone modifications in the nucleosome core may regulate DNA accessibility. This study proposes a model where these modifications influence nucleosome dynamics and the histone code.

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Chromatin Biology

Background:

  • Post-translational modifications (PTMs) on histone tails are known regulators of chromatin states and DNA accessibility.
  • Emerging research indicates PTMs also occur within the nucleosome core, at the interface between histones and DNA.

Purpose of the Study:

  • To integrate new proteomic findings on nucleosome core PTMs with existing knowledge.
  • To propose a novel, testable model explaining how these modifications impact nucleosome dynamics and the histone code.

Main Methods:

  • Review and interpretation of recent proteomic analyses identifying new histone PTMs.
  • Integration of these findings with previously published data on histone modifications and chromatin structure.

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Main Results:

  • Identification of numerous novel PTMs within the nucleosome core, particularly at the histone-DNA interface.
  • These core PTMs are hypothesized to play a significant role in regulating DNA accessibility.

Conclusions:

  • The histone code extends beyond histone tails to include modifications in the nucleosome core.
  • Modulation of nucleosome dynamics by core PTMs offers a new mechanism for epigenetic regulation.