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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
[Autologous transfusion -- from euphoria to reason: clinical practice based on scientific knowledge (Part II).
G Kühbacher-Luz1, P Innerhofer
1Univ.-Klinik für Anästhesie u. Allgemeine Intensivmedizin, Medizinische Universität Innsbruck, Innsbruck, Osterreich. gabriele.kuehbacher@uibk.ac.at
Insights
Blood-saving strategies are crucial for pediatric patients, but age-specific challenges limit their application. Recent advancements and combined techniques have significantly reduced the need for allogeneic blood transfusions in children.
Area of Science:
- Pediatric Anesthesiology
- Transfusion Medicine
- Surgical Hemostasis
Context:
- Blood-saving strategies are well-established in adults but underutilized in children due to physiological and technical limitations.
- Limited compensatory mechanisms in younger children restrict the applicability of certain perioperative blood management techniques.
- Age-specific considerations are vital, as small blood loss relative to total volume can necessitate transfusions in infants.
Purpose:
- To review the applicability and limitations of various blood-saving strategies in pediatric patients.
- To highlight age-appropriate techniques for minimizing allogeneic blood transfusions in children.
- To discuss supporting measures that reduce the reliance on blood products during pediatric surgery.
Summary:
- Perioperative techniques have limited benefit in infants; preoperative autologous donation is suitable for older children and adolescents.
- Intraoperative blood salvage is effective from one year of age with expected blood loss exceeding 20% of blood volume.
- Acute normovolemic hemodilution and deliberate hypotension are recommended only in children with robust cardiovascular compensatory mechanisms.
Impact:
- Combined blood-saving strategies, including erythropoietin, iron supplementation, surgical techniques, and hemostasis, significantly decrease the need for allogeneic blood in children.
- Defining age-specific, low transfusion triggers further optimizes blood product utilization.
- These advancements improve patient safety and resource management in pediatric care.
Abstract:
It is uncontested that blood-saving strategies should also be applied in children. However, in the past, blood-saving techniques saw limited use in children, although they are well-established in adults. This is due to technical and methodical problems, but also to the physiologically limited compensatory mechanisms for diminished oxygen delivery in this age group. For this reason, the various blood saving-techniques cannot be universally applied to all age groups. During the first year of life most perioperative techniques are of only limited benefit: even only a small amount of blood loss in relation to total blood volume makes a transfusion of allogeneic blood necessary, which is far before enough shed blood can be recovered for retransfusion. Preoperative autologous donation of blood calls for a high degree of cooperation by the child and the parents an is equally demanding in terms of organization and skills. Therefore, this procedure is used mainly in school-age children and in adolescents. Intraoperative blood salvage, by contrast, is already worthwhile in children from age one year with an expected blood loss of 20 % of blood volume. Acute normovolemic hemodilution and deliberate hypotension should be recommended only in an age group where cardiovascular compensatory mechanisms are given. Supporting procedures aimed at avoiding the need for allogeneic blood include perioperative administration of erythropoietin, iron supplementation, blood-saving surgical techniques and careful hemostasis. These prerequisites, the combination of various techniques, as well as the definition of an age-specific low transfusion trigger have contributed to a marked decrease in the need for allogeneic blood products in children in recent years.
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