Related Experiment Video
Updated: Aug 3, 2026

Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond
Published on: June 24, 2015
Influence of time-delayed feedback in the firing pattern of thermally sensitive neurons
M Sainz-Trapága1, C Masoller, H A Braun
1Departamento de Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.
Abstract:
We explore the dynamics of a Hodgkin-Huxley-type model for thermally sensitive neurons that exhibit intrinsic oscillatory activity. The model is modified to include a feedback loop that is represented by two parameters: the synaptic strength and the transmission delay time. We analyze the dynamics of the neuron depending on the temperature, the synaptic strength, and the delay time. We find parameter regions where the effect of the recurrent connexion is excitatory, inducing spikes or trains of spikes, and regions where it is inhibitory, reducing or eliminating completely the spiking behavior. We characterize the complex interplay of the intrinsic dynamics of the neuron with the recurrent feedback input and a noisy input.
Related Concept Videos
Thermosensation
The Role of Ion Channels in Neuronal Computation
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential.
Graded Potential
Graded potentials fall into two categories: depolarizing and hyperpolarizing. Depolarizing graded potentials typically occur when sodium (Na+) or calcium...
Integration of Synaptic Events
Neural Circuits
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...

