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MicroRNAs guide asymmetric DNA modifications guiding asymmetric organs

Yuval Eshed1, John L Bowman

  • 1Department of Plant Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel.

Developmental Cell
|November 5, 2004
PubMed

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RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...