Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

11beta-hydroxysteroid dehydrogenases: changing glucocorticoid action.

Jonathan R Seckl1

  • 1Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, UK. J.Seckl@ed.ac.uk

Current Opinion in Pharmacology
|November 5, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ten Year Outcome of Anti-Thyroid Drug Treatment for First Episode Graves' Thyrotoxicosis: The Predictive Importance of TRAb.

Clinical endocrinology·2025
Same author

Low plasma glucose results in non-diabetic adults referred from primary care are not associated with morbidity, mortality, or underlying endogenous hypoglycemic disorders.

Endocrine·2023
Same author

11β-Hydroxysteroid dehydrogenase 1 deficiency prevents PTSD-like memory in young adult mice.

Psychoneuroendocrinology·2022
Same author

Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments.

Wellcome open research·2022
Same author

Hair glucocorticoids are associated with childhood adversity, depressive symptoms and reduced global and lobar grey matter in Generation Scotland.

Translational psychiatry·2021
Same author

Face coverings and respiratory tract droplet dispersion.

Royal Society open science·2021

11beta-hydroxysteroid dehydrogenases (11beta-HSDs) regulate cortisol activity. 11beta-HSD1 amplifies cortisol, potentially causing metabolic syndrome, while 11beta-HSD2 inactivates it, protecting tissues.

Area of Science:

  • Biochemistry
  • Endocrinology
  • Metabolic Research

Background:

  • 11beta-hydroxysteroid dehydrogenases (11beta-HSDs) are critical enzymes.
  • They interconvert active cortisol and inactive cortisone.
  • Two isozymes, 11beta-HSD1 and 11beta-HSD2, possess distinct functions.

Purpose of the Study:

  • To elucidate the specific roles of 11beta-HSD isozymes.
  • To explore the involvement of 11beta-HSD1 in metabolic syndrome.
  • To identify therapeutic targets for metabolic and CNS disorders.

Main Methods:

  • Enzyme activity assays.
  • Gene expression analysis.
  • Tissue-specific function studies.

Main Results:

Related Experiment Videos

  • 11beta-HSD2 efficiently inactivates cortisol, safeguarding vital organs.
  • 11beta-HSD1 regenerates cortisol, enhancing its effects in the liver, adipose tissue, and brain.
  • Overexpression of 11beta-HSD1 is implicated in metabolic syndrome development.

Conclusions:

  • Differential roles of 11beta-HSD isozymes are crucial for hormonal balance.
  • 11beta-HSD1 is a potential therapeutic target for metabolic disorders.
  • Inhibiting 11beta-HSD1 may offer treatments for CNS conditions linked to glucocorticoids.